Abstract
A novel series of non-nucleoside HCV NS5B polymerase inhibitors was prepared from a (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid template. Solution and solid phase analog synthesis focused on the northern region of the template combined with structure based design led to the discovery of several potent and orally bioavailable lead compounds.
MeSH terms
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Acrylates / chemistry*
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Acrylates / pharmacology*
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Enzyme Inhibitors / chemistry*
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Enzyme Inhibitors / pharmacology*
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RNA-Dependent RNA Polymerase / antagonists & inhibitors*
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Viral Nonstructural Proteins / antagonists & inhibitors*
Substances
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(2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid
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Acrylates
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Enzyme Inhibitors
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Viral Nonstructural Proteins
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NS-5 protein, hepatitis C virus
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RNA-Dependent RNA Polymerase